ISSN 2277 - 3681
Indexing & Listing
Impact Factor-2.633
(JIF-2015)
Journal of
Pharmaceutical Science and Bioscientific Research
Volume 10
Issue 2, 2020
RP-HPLC Method Development and Validation for Simultaneous Estimation of Bisoprolol Fumarate and
Cilnidipine in Pharmaceutical Dosage Form
Shubhada Pawar*, Ashpak Tamboli, Snehal Patil
Gallic acid Biological Activities: A review
Khaled Rashed
Microspheres of Beclomethasone Dipropionate
Vishakha Vishwanath Doke*, Nilesh M. Khutle, Khemchand Gupta, Abhijeet Kunwarpuria
A case report on the effects of onion steam vapour/nebulisation and T-AYU-HM Premium tablets in Covid-19 patient
Atul Desai, Kavita Desai Hemshree Desai, Chirag Desai, Rutvij Desai
Pharmacological Evidences and chemical compounds of Platonia insignis Mart.: A review
Khaled Rashed
ABSTRACT:
Platonia insignis Mart., is a plant from Clusiaceae family. It is a native tropical fruit from the Brazilian
Amazon and Northeast Regions. Its seeds was used to treat inflammatory diseases, diarrhea and skin
problems intraditional medical practices. The bark is astringent and it was used to treat diarrhea.
Chemical composition showed high water content (76%), 20% of carbohydrate, 3% of lipids, less than
1% of proteins and other chemical compounds. Pharmacological studies proved its bactericide,
antifungal, spasmogenic and anti-protozoal activities.
KEY WORDS: Platonia insignis, phytoconstiuents, plants, bioactivities
![[x]](Issue_1_htm_files/close.png "Close")
ABSTRACT:
Phenolic acids are diverse group that includes hydroxybenzoic and hydroxycinnamic acids. Various
phenolic acids reported from plants are gallic, and ellagic acids. They are also of interest in food, cosmetic
and pharmaceutical industries as well as substitutes for synthetic antioxidants. One such prominent
phenolic acid is gallic acid which is found in a wide variety of vegetables, fruits, tea, coffee and wine. It
occurs in plants in the form of free acids, esters, catechin derivatives and hydrolysable tannins. It also
occurs as methylated gallic acids e.g., syringic acid or galloyl conjugates of catechin derivatives, i.e.,
flanvan-3-ols, or polygalloyl esters of glucose, quinic acid or glycerol. Gallic acid has been reported to elicit
various biological activities such as antibacterial, anti-fungal, antiviral, anti-inflammatory, antioxidant,
anticancer, anti-diabetic effects.
KEY WORDS: Gallic acid, phenolic acids, plants, bioactivities
ABSTRACT:
The research was done with the goal of development and evaluation of sustained release microsphere of
Beclomethasone dipropionate (BDP) by microencapsulation process. Poly lactic glycolic acid (PLGA) was used
as polymer and Polyvinyl alcohol (PVA) was used as emulsifying agent and concentration of both was optimized
on the basis of entrapment efficiency. Microspheres were prepared using emulsion solvent evaporation method.
Two different formulations were prepared using two different grades of PLGA i.e. PLGA 50: 50 and PLGA 75:25.
It was found that 20 to 40 mg PLGA with 1-3% w/v PVA gives good entrapment efficiency. Optimized batch was
selected using 32 factorial design. For BDP-PLGA 50:50 microspheres, batch containing 30 mg PLGA and 2%
w/v PVA and for BDP-PLGA 75:25 microsphere, batch containing 20 mg PLGA and 2% w/v PVA was found to be
best. A microsphere was filled in capsule shell size “2”. Optimized batch was then evaluated for particle size
which is in the range of 3000-6000 nm, zeta potential was found to be -10 to -19 mV, entrapment efficiency was
found to be 97-98%. Microspheres had good flow properties, ex-vivo permeability study shows 40% release of
BDP in 4 hrs. An optimized microsphere shows significant improvement in dissolution behaviour. It gives above
98% release in 24 hrs. DSC confirmed that there is entrapment of drug in polymer.
KEY WORDS: Beclomethasone dipropionate (BDP), Poly lactic glycolic acid (PLGA) and Polyvinyl alcohol
(PVA).
ABSTRACT
Currently, every nation is passing through a tough phase because of Covid-19. Traditional system of medicine
definitely has potential to help in fighting against this covid-19 pandemic. Boosting immunity has gained much
attention during these days and people are receiving multiple options for the same. Complications and treatment of
patients of Covid-19 having comorbidities presents a major challenge in current timings. In this article, we present a
clinical case study of a 51-year-old male weighing 73.60 kg, complaining of fever, cough, cold, breathing difficulty,
weakness, loss of taste sensation and vertigo. He also had a history of Type II Diabetes Mellitus and was on Glimi-M
twice a day. He was suspected of being infected by Covid-19. During his home quarantine tenure, we advised him to
take onion nebulisation and tablet T-AYU-HM Premium 300mg twice a day for 15 days. On his follow up visit, we
observed a remarkable improvement in his ESR, CRP and white blood cell count. He showed 20-30 percent
involvement of lungs in HRCT Chest conducted on the 5th day of his treatment. His SpO2 and Body Temperature
maintained normal levels throughout all 10 days of observation period. Tablet Levocetrizine 5mg with Montelukast
10mg was added as a supportive medication and Tablet Paracetamol 650mg was advised to be given only when he
had fever above 100°F. We observed proper home quarantine measures and treatment with Onion steam
vapour/Nebulisation and T-AYU-HM Premium does show a remarkable effect in reducing the clinical and pathological
sign and symptoms of the patient.
KEY WORDS: Covid-19, Onion Stem Vapour/Nebulisation, T-AYU-HM Premium, ESR, CRP
ABSTRACT:
Platonia insignis Mart., is a plant from Clusiaceae family. It is a native tropical fruit from the Brazilian Amazon and
Northeast Regions. Its seeds was used to treat inflammatory diseases, diarrhea and skin problems intraditional
medical practices. The bark is astringent and it was used to treat diarrhea. Chemical composition showed high water
content (76%), 20% of carbohydrate, 3% of lipids, less than 1% of proteins and other chemical compounds.
Pharmacological studies proved its bactericide, antifungal, spasmogenic and anti-protozoal activities.
KEY WORDS: Platonia insignis, phytoconstiuents, plants, bioactivities
