VOLUME 13, ISSUE 02
Ethanopharmacology of Vitex Negundo
Raman Dinesh Yadav, Pankti Dalwadi, Nishith Patel
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Design and Evaluation of Aprepitant Liposomal Formulation
Bhavik patel, Priyanka Patel, Harsh Chunara, Nishith K Patel
Formulation and Evaluation of Kojic Acid Dipalmitate-Loaded Nanofibers for the Treatment of Hyperpigmentation: A
Comprehensive Review
Shashank Rai, Nishith K Patel
Formulation and Evaluation of Mesalamine Microspheres for Controlled Drug Release in the Treatment of Ulcerative Colitis
Udita Kharbikar, Harsh Chunara, Akash Vaghela, Nishith K. Patel
ABSTRACT:
The study focused on evaluating the stability of three antihypertensive combinations: Azilsartan medoxomil and cilnidipine
(AZL-CIL), Efonidipine hydrochloride ethanolate and telmisartan (EFO-TEL), and Fimasartan potassium trihydrate and
chlorthalidone (FIMA-CHL). Under various stress conditions, AZL-CIL experienced degradation ranging from 10.06% to
16.7%, while EFO-TEL showed degradation between 8.26% and 15.65%, and FIMA-CHL exhibited degradation from 6.81%
to 16.24%. Robust RP-HPLC methods were developed, demonstrating strong linearity (R2 values ranging from 0.9977 to
0.9997), precise repeatability (RSD < 2%), and low LOD and LOQ values (ranging from 0.150 to 0.650 µg/mL). The research
provides critical insights into these combinations' stability and presents validated RP-HPLC methods for accurate
quantification, crucial for ensuring the efficacy and safety of these antihypertensive medications.
KEY WORDS:Antihypertensive combinations, stability, forced degradation, HPLC, method validation, degradation products,
pharmaceutical analysis, drug stability
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ABSTRACT:
Phytoconstituents, such as ellagic acid and eugenol, exhibit remarkable therapeutic properties, but their limited skin penetration has been a
persistent challenge in dermatological applications. This comprehensive review explores the formulation, development, and evaluation of
phytosomes as a promising strategy to improve the skin permeation of these bioactive compounds. Phytosomes, phospholipid complexes of
phytoconstituents, have gained considerable attention due to their ability to enhance solubility, stability, and bioavailability. This review
provides insights into the various methods employed for the preparation of ellagic acid and eugenol-loaded phytosomes, emphasizing recent
innovations in formulation techniques. Additionally, it discusses the factors influencing the skin penetration of phytosomal formulations,
including particle size, lipid composition, and penetration enhancers. The review critically assesses in vitro and in vivo studies conducted to
evaluate the efficacy of phytosomes in enhancing skin permeation, highlighting the potential benefits in the treatment of skin disorders and
the development of novel cosmetic products. Furthermore, safety considerations, regulatory aspects, and future perspectives on the
commercialization of phytosome-based formulations are addressed.
KEY WORDS: Phytosomes, skin penetration, bioavailability, formulation, dermatology, phytoconstituents, permeation enhancers
ABSTRACT:
Obesity and overweight have posed a serious threat to humanity, requiring urgent efforts to establish secure and efficient
therapeutic methods. Additionally, it is a metabolic condition that represents a risk to life and calls for the rapid
development of effective and secure treatment. There are now only a limited number of such therapy options accessible
for obesity. The present study evaluated the anti-obesity effects of Coleus forskohlii also known as Colegex® in high-fat
diet -induced obese mice. Five groups of six mice each were divided from the 30 C57 black male mice. Group I was
provided with a normal control and received 0.5% CMC, while Group II was given a high-fat diet condition and received
0.5% CMC as well. Rosuvastatin, 10 mg/kg b.w. was received by Group III as a reference standard. Colegex® was given
to Group IV at a low dose, 205.41 mg/kg b.w. and to Group V at a high dose, 308.25 mg/kg b.w. daily with HFD for 28
days. Body weight and food intake were measured during the study period. On the 29th day of the study period,
biochemical analyses, including lipid profile tests, renal function tests, and liver function tests, were evaluated. The
results of this study clearly proved that Colegex® treatments effectively reduced the accumulation of adipose tissue and
lowered blood cholesterol, triglycerides, and LDL levels while elevating HDL levels in HFD-induced obese mice.
Therefore, this study suggests that it may be useful in reducing obesity.
KEYWORDS: Coleus forskohlii, Colegex®, HFD-induced, Rosuvastatin, Body weight, food intake, biochemical
analyses, Weight Management
ABSTRACT:
Traditional herbal plant is still preferred as primary health care system in my , with over 60% of world’s population and about 80% in developing
countries depending on their medical purpose. Female health refers to health issue specific to female anatomy. These often relate to structure
such as female genitalia and breast or to condition caused by hormones specific to female. Female health issue includes gynaecological cancer,
PCOS, endometriosis, breast cancer, pregnancy issues. Benefit of herbal therapy compared to conventional therapy is that herbal therapy is safe
with lesser side effects and presence of multiple active compounds in medicinal herbs altogether provides a potentiating effect. This review focus
on different female diseases and some popular herbal remedies for treatment of this condition
KEYWORDS: Herbal Drug, Herbal plant, PCOD, Endometriosis, Uterine fibroids, Interstitial cystitis, Female related cancer
