VOLUME 13, ISSUE 03
Development and Evaluation of Ethosomal Clascoterone Cream: A Promising Approach for Acne Therapy
Chintan J. Chavda, Nishith K. Patel, Zalak B. Patel
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Formulation and Evaluation of Solid Self-Nanoemulsifying Drug Delivery System of Apixaban
Abbas Moiyadi, Nishith K.Patel, Aakashsinh Vaghela
Stability Indicating RP-HPLC Method Development and Validation for Simultaneous Estimation of Crotamiton and
Hydrocortisone in Topical Formulation
Meet Patel, Nachiket Pandya, Vanita Marvaniya, Nishith K. Patel
Development and Validation of HPLC method for quantitative estimation of Vilanterol Trifenatate and Glycopyrrolate from
synthetic mixture
Bhavsar Dipti, Vanita Marvaniya, Bhumi Patel, Nachiketa Pandiya, Nishith K. Patel
ABSTRACT:
BCS Class IV drug is limited by its poor aqueous solubility and variable pharmacokinetics, further, such an anti-emetic agent
leads to suboptimal management of chemotherapy-induced nausea and vomiting (CINV) in cancer patients, particularly those
with breast, lung, and colorectal cancer. This study aims to design and evaluate a liposomal formulation of a BCS Class IV
antiemetic drug to enhance its solubility, stability, and bioavailability, thereby improving its therapeutic efficacy in CINV
management. Several methods can be used to prepare and characterize their size, zeta potential, and entrapment efficiency.
KEYWORDS: liposomal formulation, solubility, bioavailability, pharmacokinetics, chemotherapy-induced nausea and vomiting
(CINV), cancer, BCS Class IV.
![[x]](issue1_htm_files/close.png "Close")
ABSTRACT:
TRecently, a newly anti-diabetic tablet formulation of Teneligliptin hydrobromide hydrate, Pioglitazone hydrochloride and Metformin
hydrochloride was approved by CDSCO. Following ICH guidelines, the RP-HPLC method has been designed and validated for
simultaneous estimation of Teneligliptin hydrobromide hydrate, Pioglitazone hydrochloride and Metformin hydrochloride in bulk and
recently approved triple FDC. These 3 drugs were easily separated by 0.025 M KH2PO4 Buffer: Methanol: Acetonitrile (50:25:25 % v/v/v)
at pH 3 at 225 nm wavelength and 1mL/min flow rate. The linear graph was obtained for 2-6 µg/mL- Teneligliptin hydrobromide hydrate,
1.5- 4.5 µg/mL for Pioglitazone hydrochloride and 50-150 µg/mL for Metformin hydrochloride. % Relative standard deviation was less than
2% for precision. The limit of detection (LOD) and limit of quantitation (LOQ) were found to be 0.021 and 1.159 μg/mL for Teneligliptin
hydrobromide hydrate, 4.718 and 14.298 μg/mL for metformin hydrochloride and 0.417 and 1.189 μg/mL for Pioglitazone hydrochloride.
KEYWORDS: RP-HPLC, Degradation study, Teneligliptin hydrobromide hydrate, Metformin hydrochloride and Pioglitazone hydrochloride.
ABSTRACT:
The comprehensive overview gazed at the current state of the art use of curcumin-loaded nanofibers made by
electrospinning as an implanted cancer medication delivery system. The powerful anticancer properties of curcumin, a
naturally occurring polyphenol, are well known. Still, its quick systemic metabolism, low bioavailability, and poor water
solubility make it difficult to translate into clinical practice. A clever way around these obstacles is to use electrospun
nanofibers, which provide curcumin with a flexible encapsulation medium and allow for regulated release kinetics. By
carefully regulating factors like polymer makeup, fiber structure, and medication loading, electrospun nanofibers show
great promise for improving curcumin stability, and solubility, delaying its release, and enabling tailored administration
to malignant regions. This study highlights the curcumin loaded nanofiber's potential efficacy and safety profiles in
preclinical investigations while thoroughly examining their production methods, physicochemical characteristics, and
biological applications. It also addresses the difficulties that lie ahead and potential paths forward in integrating this
cutting edge technology into clinical practice and transforming cancer treatment approaches.
KEYWORDS: Implantable drug delivery system, Curcumin, Nanofibers, Electrospinning method, and Cancer.
ABSTRACT:
Drugs can be administered sublingually instead of orally. The effectiveness of sublingual administration is greater when a quick onset of action is
needed. Its excellent bioavailability can be attributed to avoiding hepatic first-pass metabolism. A recent study has shown that polymer nanofibers
are being studied more because of their incredible qualities, like high porosity and a high surface area to volume ratio. Geriatric patients often face
multiple chronic diseases requiring the use of many drugs. The electrospun nanofiber system offers a promising alternative to conventional oral
dosage forms, such as tablets and capsules. This system produces ultrafine fibers that provide faster drug release, improved bioavailability, and
lower dosages. It can be administered in various forms, such as patches and films, and has shown higher efficacy and greater patient compliance
than oral dosage forms. It is a viable option for the treatment of multiple chronic diseases. Electrospinning technology is a highly efficient and reliable
manufacturing technique that has garnered significant attention in recent times. Its simplicity and repeatability make it a desirable option for a range
of applications. This method is an efficient and cost-effective way to produce continuous nanofibers with desirable properties. These properties
include high porosity, high surface area to volume ratio, high loading capacity, high encapsulation efficiency, transport of various medications, and
increased drug solubility. Electrospun polymeric nanofibers have important applications in wound healing and the treatment of various conditions
such as diabetes, AIDS, cancer, and migraines, asthma.
KEYWORDS: Sublingual, polymer, electrospinning, drug delivery.
