jpsbr issues

ABSTRACT: Ketorolac tromethamine, a potent nonsteroidal anti-inflammatory medicine (NSAID), has been considerably used for the treatment of moderate to severe pain. The original conflation of ketorolac involves a multistep process that requires harsh response conditions and produces a significant quantum of waste. Over the times, colourful synthetic styles have been developed to ameliorate the effectiveness and environmental knowledge of ketorolac product. This review paper provides a comprehensive overview of the different synthetic approaches for ketorolac. It discusses the advantages and disadvantages of each system and highlights the recent advancements in the field. The paper also accentuates the significance of green chemistry principles in the conflation of ketorolac and other Medicinals. The review concludes that the conflation of ketorolac has experienced significant advancements in recent times, still, there's still a need for further development of more effective, environmentally friendly, and cost-effective synthetic styles.A RP-HPLC method was developed and validated to quantify the Ketorolac Tromethamine in eye drops.. KEYWORDS: RP-HPLC Method, Chromatographic, Validation

ABSTRACT: TRecently, a newly anti-diabetic tablet formulation of Teneligliptin hydrobromide hydrate, Pioglitazone hydrochloride and Metformin hydrochloride was approved by CDSCO. Following ICH guidelines, the RP-HPLC method has been designed and validated for simultaneous estimation of Teneligliptin hydrobromide hydrate, Pioglitazone hydrochloride and Metformin hydrochloride in bulk and recently approved triple FDC. These 3 drugs were easily separated by 0.025 M KH2PO4 Buffer: Methanol: Acetonitrile (50:25:25 % v/v/v) at pH 3 at 225 nm wavelength and 1mL/min flow rate. The linear graph was obtained for 2-6 µg/mL- Teneligliptin hydrobromide hydrate, 1.5- 4.5 µg/mL for Pioglitazone hydrochloride and 50-150 µg/mL for Metformin hydrochloride. % Relative standard deviation was less than 2% for precision. The limit of detection (LOD) and limit of quantitation (LOQ) were found to be 0.021 and 1.159 μg/mL for Teneligliptin hydrobromide hydrate, 4.718 and 14.298 μg/mL for metformin hydrochloride and 0.417 and 1.189 μg/mL for Pioglitazone hydrochloride. KEYWORDS: RP-HPLC, Degradation study, Teneligliptin hydrobromide hydrate, Metformin hydrochloride and Pioglitazone hydrochloride.

ABSTRACT: The comprehensive overview gazed at the current state of the art use of curcumin-loaded nanofibers made by electrospinning as an implanted cancer medication delivery system. The powerful anticancer properties of curcumin, a naturally occurring polyphenol, are well known. Still, its quick systemic metabolism, low bioavailability, and poor water solubility make it difficult to translate into clinical practice. A clever way around these obstacles is to use electrospun nanofibers, which provide curcumin with a flexible encapsulation medium and allow for regulated release kinetics. By carefully regulating factors like polymer makeup, fiber structure, and medication loading, electrospun nanofibers show great promise for improving curcumin stability, and solubility, delaying its release, and enabling tailored administration to malignant regions. This study highlights the curcumin loaded nanofiber's potential efficacy and safety profiles in preclinical investigations while thoroughly examining their production methods, physicochemical characteristics, and biological applications. It also addresses the difficulties that lie ahead and potential paths forward in integrating this cutting edge technology into clinical practice and transforming cancer treatment approaches. KEYWORDS: Implantable drug delivery system, Curcumin, Nanofibers, Electrospinning method, and Cancer.

ABSTRACT: Drugs can be administered sublingually instead of orally. The effectiveness of sublingual administration is greater when a quick onset of action is needed. Its excellent bioavailability can be attributed to avoiding hepatic first-pass metabolism. A recent study has shown that polymer nanofibers are being studied more because of their incredible qualities, like high porosity and a high surface area to volume ratio. Geriatric patients often face multiple chronic diseases requiring the use of many drugs. The electrospun nanofiber system offers a promising alternative to conventional oral dosage forms, such as tablets and capsules. This system produces ultrafine fibers that provide faster drug release, improved bioavailability, and lower dosages. It can be administered in various forms, such as patches and films, and has shown higher efficacy and greater patient compliance than oral dosage forms. It is a viable option for the treatment of multiple chronic diseases. Electrospinning technology is a highly efficient and reliable manufacturing technique that has garnered significant attention in recent times. Its simplicity and repeatability make it a desirable option for a range of applications. This method is an efficient and cost-effective way to produce continuous nanofibers with desirable properties. These properties include high porosity, high surface area to volume ratio, high loading capacity, high encapsulation efficiency, transport of various medications, and increased drug solubility. Electrospun polymeric nanofibers have important applications in wound healing and the treatment of various conditions such as diabetes, AIDS, cancer, and migraines, asthma. KEYWORDS: Sublingual, polymer, electrospinning, drug delivery.

ABSTRACT: Topical/Transdermal drug delivery systems (TDDS) have been designed for drug delivery through the skin. These systems use the permeability property of stratum corneum, the outermost surface layer of the skin. Applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the preferred method for polymeric micro-nanofibers fabrication with a great potential for drug delivery. More studies in the field of nanofibers containing drug are divided two categories: first, preparation and characterization of nanofibers containing drug and second, investigation of their therapeutic applications. Drugs used in electro spun nanofibers can be categorized into three main groups, including antibiotics and antimicrobial agents, anti-inflammatory agents and vitamins with therapeutic applications. Electrospinning is the method for preparing drug-loaded nanofibers with ultrafine structure, a large surface area to volume ratio, and a high porosity with a small pore size. Among the other nanofiber production methods, electrospinning is the most cost effective one with simple tooling and, it is applicable to produce ultrafine fibers with a simple step-up production for drug delivery applications. The selection of the polymer as carrier for electrospinning and the production procedure design is crucial due to drug-polymer-solvent interactions and the other process parameters which would influence the physicochemical biocompatibility and characteristics. This technique can be applied to produce nanofibers of a wide array of polymer types: natural, synthetic polymers, or their blends. This review focuses on various electrospinning methods to produce drug loaded nanofibers, polymers used, electrospinning process parameters, their advantages and limitations for topical. KEYWORDS: Drug Delivery, Electrospinning, Nanofiber, Polymeric Scaffold, Topical /transdermal drug delivery applications.