Formulation and Evaluation of Fast Disintegrating Tablets of Fluoxetine and Olanzapine
Nishtha P. Patel , Dipal M. Patel , Dhaval Patel
A Review of Research Study on - Self Nanoemulsifying Drug Delivery System
Najuka D. Bhanse, C. N. Shah
Volume 6, Issue 5, Pages no. 611-752 , ISSN 2277-3681
Available online on 1st September 2016
J Pharm Sci Bioscientific Res. 2016; 6(5):611-752sz
Process Validation of Aripiprazole Tablets
Nitesh Patel
Selected Physico-Chemical Parameters of Ground Water from Limbdi Taluka of Surendranagar District-Gujarat
Mahesh B. Chauhan, Kiran S. Nimavat, Neetu Shorgar, Shilpa. N. Pandya, Dipak K. Bhoi
In-Vitro Cytotoxicity of Leaf of Gendarussa Vulgaris on MCF 7 and Vero Cell Line
Jay Dasadia, Vivek Vyas, Sonal Patel, Maitreyi Zaveri
Formulation and In Vitro Evaluation of Orodispersible Film of Torsemide
Jayesh G. Bariya, Hiral D. Koradia
Isolation of Root Surface (Rhizoplane) Mycoflora From Medicinal Plants of Akola
V.S.Patil, S.O.Morkhade
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pH Sensitive in Situ Ocular Gel: A Review
Suresh Chand , Abhishek Sharma
Prevalence of Diabetes Mellitus in Raysan Village, Gandhinagar, Gujarat, India
Paras A. Shah, Deep K. Patel, Rohit R. Patel
A Review of Recent Research on Herbal Formulation: An Ayurvedic Medicine- The Nature’s Boon
Nidhi P. Desai, Chainesh N. Shah
Review on Liquisolid Compacts: A Novel Approach to Enhance Solubility of Poorly Soluble Drugs
Urvashi B. Patel. Dixit Modi. . Chainesh N. Shah, Harshil M. Patel
Novel thiophene derivatives as Anti-inflammatory agents
Dharmistha Parmar, M. T. Chhabria
A Review on High Performance Liquid Chromatography Analytical method development
Suleman S. khoja Parthkumar H. Chauhan, Maulik N. Patel, Harsha D. Jani
Review on Chronotherapy: A Novel Drug Delivery System
Amitha Shetty, Theivendren Paneer Selvam
A Recent Research Review- Development and Validation with liquid chromatography
Bhavesh R. Sharma, Chainesh N. Shah
Method Validation and Method Development by using Analytical Method- HPLC- Review on Current Research
Ragini A. Patel, Chainesh N. Shah
Development and Validation of Spectrophotometric Method for Metformin and Sitagliptin by Absorbance Ratio Method
Madhuri Hinge, Keyuree Vishnubhai Patel
A Review-Recent Research on Liquisolid Compact For Solubility & Dissolution Enhancement
Harshil M. Patel, Chainesh N. Shah
Formulation and Evaluation of Spironolactone Loaded Emulgel for Topical Application
Bhautik Kapadiya*, Dipti Gohil, Dinal Patel, Snehal Patel, Chintan Aundhia, Nirmal Shah, Kartik Pandya, Chainesh Shah
ABSTRACT:
The aim of present study was to formulate fast disintegrating tablets of Fluoxetine and Olanzapine. FDT of FLX & OLZ helps in
swallowing problem for the patients. Fluoxetine is an anti depressive and serotonin agent. Fluoxetine is readily absorbed from GI tract
following oral administration. Half life of FLX is 1-3 days. Olanzapine is an anti psychotic agent. Olanzapine absorbed from the GI tract.
Half life of Olanzapine is 33hours. Olanzapine is used in treatment of schizophrenia. FDTs improved clinical effects of bipolar disorder,
leading to quick onset of action of Fluoxetine and Olanzapine. The study was design to optimize aqueous solubility and dissolution rate
of Olanzapine by solid dispersion using PVPK30 water soluble carriers in different concentration (1:1, 1:2, 1:3, and 1:4).
Characterization of prepared solid dispersion was carried out using methods such as FTIR and DSC. Fast disintegrating tablets were
formulated by using PVPK30 as polymer, superdisintegrants like cross-carmellose sodium, sodium starch glycolate, and crosspovidone,
MCC as binder, mannitol as diluent, magnesium stearate as lubricant and talc as glident. The prepared tablets were evaluated for
number of parameters like weight variation, hardness, friability, in vitro dissolution study and stability study. The best release for FDT
was shown by formulation F8 as compare to the marketed conventional tablets and less disintegration time of F8 formulation is 27 sec.
Drug release of F8 formulation after 30minutes more than 85%. Drug and polymer interaction is not found shown in FTIR. F8
formulation was found to be stable
Key words: Fluoxetine, Olanzapine, Fast disintegrating tablets.
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ABSTRACT:
The Self Nanoemulsifying Drug Delivery System (SNEDDS) is a Novel Drug Delivery System for Enhancement of water solubility of poorly
water soluble drugs. It is isotropic mixture of oil, surfactant, cosurfactant molecules and it also containing co-solvent molecule. It is Drug
delivery system is thermodynamicallyand kinetically stable. The drug delivery system under mild agitation is followed by dilution of aqueous
media such as GI fluid and it can from stable O/W Nanoemulsion. Having size of Globules is less than 100nm. It is important type of Drug
delivery system to maintain the chemical stability as well as solubility of drug product. The Self Nanoemulsifying Drug Delivery System
(SNEDDS) is important application on BCS Class II and Class IV Drugs for improving water Solubility of poorly water soluble drugs. It is
important to prevent the interfacial tension and improving the dissolution as well as absorption rate of drug molecule. It is Novel Drug
Delivery System is Applicable for parenteral, Ophthalmic, intranasal and cosmetic drug delivery system. And the present review describes
Preparation, components, mechanism, of self Nanoemulsification biopharmaceutical aspects, characterization methods and applications of
self Nanoemulsifying drug delivery system (SNEDDS) For Enhancement of oral Bioavailability of poorly water soluble drugs.
KEYWORDS: Nanoemulsion, Miniemulsion, Submicron Emulsion, Self-emulsifying, Psedoternary Phase
ABSTRACT:
The main aim of the present research work was to study prospective process validation of Aripiprazole Tablets, 30 mg which
is an Antipsychotic drug. The Process Performance Qualification was carried out for three different batches having same
batch size, manufacturing process, equipments, formula and validation criteria. The critical process parameters, and critical
quality attributes involved in sifting, dry mixing, granulation, wet milling, drying, sifting & dry milling, blending and compression
were identified and evaluated as per the approved validation protocol. All the in process parameters and process
variables were checked and found well within acceptance criteria. The % LOD for dried granules after drying found out within
1.48-1.81 %. In process testing for compression (Avg. wt: 263 mg to 278 mg; hardness 4.4-7.3 Kp; thickness 3.26-3.47 mm;
friability - nil; disintegration time 1min 8 sec to 1min 50sec) and finished product (Avg. wt: 270-272 mg; dissolution: 100.00 %
to 103.00 %: assay 99.21- 100.96 %) validation found well within the limit. All the parameters and results were found within
the acceptance limit as given in validation protocol. No deviation has taken place during manufacturing of these three
batches. Considering all the parameters it was concluded that the manufacturing process and the equipments adopted were
robust enough and are capable of producing consistent quality of product continuously. Hence the manufacturing process for
Aripiprazole uncoated tablets stands validated and can be routinely used for commercial batches.
KEYWORDS: Process Validation, Aripiprazole, Critical Process Parameters, Validation Protocol.
ABSTRACT:
High Performance Liquid Chromatographic Analytical method development and validation are the continuous and inter-dependent task associated
with the research and development, quality control and quality assurance departments. Analytical procedures play a critical role in equivalence and
risk assessment, management. It helps in establishment of product-specific acceptance criteria and stability of results .Validation should
demonstrate that the analytical procedure is suitable for its intented purpose. Analyts should be comfortable to use it to characterize and optimize
the analytical method. An effective analytical method development and its validation can provide significant improvements in precision and a
reduction in bias errors. It can further help to avoid costly and time consuming exercises. The RP-HPLC strategy is precise, exact, particular,
reproducible and Sensitive .The system has advantages, including fast investigation, a straightforward portable stage, basic specimen planning,
and enhanced affectability. Method development involves the process of establishing an analytical method which is acceptable for measurement of
the concentration of an API in a specific pharmaceutical dosage form and that using validated to verify or prove that an analytical procedure,
accurately and consistently delivers a desirable specific guidelines to prove measurement of an active ingredient in pharmaceutical preparation
during each analysis
KEYWORDS: RP-HPLC, inter-dependent task, Accurasy, Stability, Specificity
ABSTRACT:
The goal in drug delivery research is to meet therapeutic needs relating to particular pathological conditions by developing new formulations.
Research in the chronopharmacological field has demonstrated the importance of biological rhythms in drug therapy, and this has brought a new
approach to the development of oral drug delivery systems. Chronotherapeutics is the discipline concerned with the delivery of drugs according to
the intrinsic activities of a disease over a certain period of time because the biochemicals, physiological and pathological variations over a 24 h
period in humans have been occurred. Chronotherapeutics deals with the medical treatment according to the human daily working cycle that
corresponds to a person's daily, monthly, seasonal or yearly biological clock or in order to maximize the health benefits and minimize the adverse
effects. The main goal of chronotherapeutics is to match the timing of treatment with the intrinsic timing of illness. Optimum therapy is given when
the right amount of drug is delivered to the correct target organ at the most appropriate time. If symptoms of a disease are varied the circadian
rhythms also varied the drug release. In the treatment of many diseases chronotherapeutics drug delivery offers a new approach in the
pharmacologic interventions design for the effective treatment in the different types of diseases. The "chronotherapeutics" term is mainly new in
the field of drug delivery and in the treatment method. It is defined as the widespread term in which disease follow the circadian rhythm which
undergoes the metabolic changes.
KEYWORDS:Chronotherapeutics, biological rhythms, metabolic changes, circadian rhythms
ABSTRACT:
Physico chemical parameters such as pH, Total dissolve solid (TDS), Total hardness, Total alkalinity, Chloride, Sulphate, Calcium,
Magnesium, Nitrate values, Chemical oxygen demand (COD), Biological oxygen demand (BOD), Fluoride and Turbidity are
measured and analysed for six station of Limbdi Taluka of Surendranagar district. All the parameter measurements are made in
terms of three different seasons such as winter, Summer and Monsoon. Results obtained are compared in terms of their highest
value and lowest values among six stations in terms of 13 parameters..
KEYWORDS: Ground water, COD, BOD, Calcium content, Turbidity
ABSTRACT:
Breast cancer remains the second most common cause of cancer death in women. Eighty per cent of women diagnosed are
alive at five years. It is the leading cause of death in women aged 40-55 years. Potential herb Gendarussa vulgaris is a
bioactive plant that has been used as an ethanomedicine to treat various diseases. This experiment is aimed to evaluate the
cytotoxic effect of the root of Gendarussa vulgaris on MCF7 cell line and vero cell line. The effect of defatted methanolic
extract of root of Gendarussa vulgaris at 100, 500, 1000 µg/ml concentration and compared with standard Vinblastine on
MCF7 cell line using MTT cell viability assay and Trypan blue assay was evaluated. MTT cell viability assay of methanolic
extract of root shows 7.3% cytotoxity at 1000µg/ml concentration in MCF 7 cell line. MTT cell viability assay of methanolic
extract of root shows 24.9 % cytotoxity at 1000µg/ml concentration in vero cell line. The methanolic root extract of
Gendarussa vulgaris does not shows cytotoxic activity in VERO &MCF 7 cell line
KEY WORDS:Gendarussa vulgaris, VERO & MCF 7 cell line, cytotoxity, MTT cell viability assay, Trypan blue assay
ABSTRACT:
The present study is aimed at developing Orodispersible film of Torsemide using solvent casting method. Films were prepared by
Solvent casting technique using HPMC E15 (Polymer), PEG 400 (Plasticizer), Crosscarmelose sodium (Super disintegrating
agent), and sodium saccharin (Sweetener). FTIR Spectra showed absence of incompatibility between drug and excipients. A 32
full factorial design was applied to investigate the combined effect of the two independent formulation variables i.e., concentration
of polymer (X1), concentration of plasticizer (X2) on the dependent variables i.e., Folding endurance (Y1), disintegration time (Y2),
%CDR at 1 min (Y3) and %CDR at 2 min (Y4). Results of the multiple regression analysis revealed that the independent variables
significantly affected the dependent variables. The optimum batch was identified. The Check point batch was formulated using
HPMC E15 (292 mg), PEG 400 (20% of polymer concentration) and 20 mg of CCS. The theoretical and practical results were
similar which confirm the prediction power of model. The stability study of optimized batch was carried out at 40 ± 0.5oC
temperature and 75 ± % 5 RH for one month. It showed no statistically significant difference in disintegration time, folding
endurance, drug content and dissolution profile before and after stability study. The optimized Orodispersible film of Torsemide can
be a promising dosage form for the treatment of poisoning.
Key words: Orodispersible film, Torsemide, Diuretic, Poisoning
ABSTRACT:
Medicinal plants from a numerically large group are economically important plants which provide basic raw materials for
medicines, perfumes, flavors and cosmetics. There plants and their products not only serve as valuable source of income for
small holders and entrepreneurs but also help the country to earn valuable foreign exchange by way of export. These plants are
those plants which are rich in secondary metabolites and are potential source of drugs. India is one of the few countries where
almost all the known medicinal plants can be cultivated in some part of the country or the other. A plant species usually has its
specific flora around its roots and on the root surface. Micro-organisms when they growing proximity, exert various kinds of
influences on one another, some of which are favorable or associative others are antagonistic. Some root diseases cause
considerable economic losses of plants. Rood diseases are in several ways different from the diseases of the aerial parts.
Acknowledge of the complex microbial interactions occurring in the soil and of the ecology of soil microorganisms, saprophytic
and parasitic are essential for a proper understanding of root diseases and for a rational approach to their control.
KEY WORDS:Medicinal plants, Root mycoflora, Rhizoplane
ABSTRACT:
Eye is the most vital organ of the body.Eye suffer from various eye problems like glaucoma, endopthalmitis, dry eye syndrome, trachoma,
keratitis, conjunctivitis etc. To achieve effective ocular therapy, an adequate amount of active ingredients must be delivered and maintain at the
site of action within the eye.To improve ophthalmic drug bioavailability, there are considerable efforts directed towards newer drug delivery
systems for ophthalmic administration. Since Conventional delivery systems often result in poor bioavailability and therapeutic response
because of high tear fluids turn over and dynamics cause rapid elimination of the drug from the eyes. Newer research in ophthalmic drug
delivery systems is directed towards a amalgamation of several drug delivery technologies, that includes to build up systems which is not only
extend the contact time of the vehicle at the ocular surface, but which at the same time slow down the removal of the drug. There are various
new dosage forms like Insitu gel, collagen shield, minidisc, ocular film, ocusert, nanosuspension, nanoparticulate system, liposomes, niosomes,
dendrimers, ocular iontophoresis etc.So, to overcome bioavailability problems, ophthalmic in situ gels were developed. This review also
summarizes various temperature, pH, and ion induced in-situ forming polymeric systems used to achieve prolonged contact time of drugs with
the cornea and increase their bioavailability thus optimizing ocular therapy.
KEYWORDS: : In situ gels, pH?triggered Insitu system, Ion?activated Insitu system, Temperature evident Insitu system.
ABSTRACT: Little work has been done on prevalence of diabetes mellitus in the rural area of Gandhinagar. This paper reports the
prevalence of both type 1 and type 2 diabetes mellitus of Raysan Village, Gandhinagar, Gujarat, India. The community based study was
conducted by home to home survey through interviewing and communication technique. Specific data collection form was prepared for
taking demographic details, medical history, medication history, past bio-chemical investigation reports, current medication. Total
population of Raysan Village was 2673 and 34 diabetic were found. So, the prevalence rate of Raysan Village in Diabetes Mellitus was
1.27%. Among 34 diabetic, 23 were male and 11 were female respectively. This report highlights the prevalence of Diabetes mellitus in
Raysan Village.
KEYWORDS:Diabetes Mellitus, Prevalence, India, Epidemiology, Rural area, Gujarat
ABSTRACT:
Ayurveda is one of the traditional systems with an established history of many centuries. Ayurveda therapy was initiated in India
thousands of years ago also known as the "Mother of All Healing". Herbal medicines have existed world-wide with long recorded history.
Due to plentiful unwanted side effects of the synthetic drugs people are nowadays shifting back to herbal drugs, which are originated
from the nature and claim to be safer. Herbal formulation starts gaining its popularity due to naturally derived with high effectiveness, low
cost and minimal side effects compared to allopathic drugs and so one can called as nature's boon. This review accounts a herbal
formulations which are made up from solely or mixture of herbs to treat different kinds of diseases that mankind suffer from like Cancer,
Diabetes, Arthritis, Fever, Fatigue, Skin diseases, Alzheimer, Joint pain, Liver diseases, Kidney stone etc.
KEYWORDS: Ayurveda, Herbal formulation, Cancer, Diabetes, Arthritis, Alzheimer, Liver diseases, Kidney stone
ABSTRACT:
A "Liquisolid" technique is a novel & capable addition towards such an aims for solubility enhancement & dissolution improvement, areby it
increases a bioavailability. It contains liquid medications in powdered form. This technique is an efficient method for formulating water
insoluble & water soluble drugs. This technique is based upon a admixture of drug loaded solutions with appropriate carrier & coating
materials. A use of non-volatile solvent causes improved wettability & ensures molecular dispersion of drug in a formulation & leads to
enhance solubility. By using hydrophobic carriers (non-volatile solvents) one can modify release (sustained release) of drugs by this
technique. Liquisolid system is characterized by flow behavior, wettability, powder bed hydrophilicity, saturation solubility, drug content,
differential scanning calorimetry, Fourier transform infra red spectroscopy, powder X-ray diffraction, scanning electron microscopy, in-vitro
release & in-vivo evaluation. By using this technique, solubility & dissolution rate can be improved, sustained drug delivery systems be
developed for a water soluble drugs.
KEY WORDS: Liquisolid compacts, Liquid medication, maamatical model, liquid load factor (LF), solubility enhancement, non-volatile
solvent, carrier, water insoluble drugs.
ABSTRACT:
Thiophene derivatives are associated with broad spectrum of biological activities. In view Synthesis ethyl 3-amino-4-cyano-5-
(substituted)thiophene-2-carboxylates were synthesized and tested for in-vivo Anti-inflammatory activity by carageenan induced rate paw
edema method. The synthetic scheme of the prepared compounds is given. All the synthesized compounds were characterized by using
IR, MS and 1H NMR spectroscopy. Compounds were screened for their in-vivo Anti-inflammatory: compound 1c showed maximum
inhibitory activity. Ibuprofen is used as standard.
KEYWORDS: Synthesis; Thiophene; Anti-inflammatory activity, H+/K+-ATPase, COX inhibitors
ABSTRACT:
Nowadays Many different methods of HPLC are uses for Development of Drugs. HPLC are used to able separate, quantify and detection
of drug and drug related substance that can form on manufacturing or storage of drugs. Different type of Chromatographic parameters
are evaluated in order for optimize the method. A mobile phase, column, temperature of column, gradient and wavelength that are use for
stability and comparability of drug and drug substance and also impurities of drugs. HPLC validation method is give all information
regarding like Accuracy, precision, specificity, linearity, range and limit of detection, limit of quantification, robustness and system
suitability testing as per guidelines of ICH.
KEYWORDS- HPLC, Method Development, Method validation
ABSTRACT:
Analytical method development is should be validated to give proper data for regulatory submission. High performance liquid
chromatography (HPLC) is very useful in the drug discovery, manufacturing process, and development of pharmaceutical materials. It is
also useful to separate manufacturing drugs from drug substance impurities, for detection and quantify the synthetic drugs and it reduce
rest impurities at the time of the separation. It is also need to ensure that safety and quality of drugs. Validation is the method of use to
the performance characteristic and its limitation of method and its identification of the influence that may replace these characteristics.
This review described the planning and the problems pertinent to designed High performance liquid chromatography (HPLC)
development of method and method validation. The force degradation studies useful in method validation and method development of
stability indicating analytical method.
KEYWORDS- Method development, HPLC, validation, force degradation.