Design and Development of pH-monitered in situ Gel of LomefloxacinJayant Deshpande, Dr. P. B Shah, Dr. Anil BhandariA Simple and Sensitive RP-HPLC Method for Estimation of Lycopene in Pharmaceutical Solid Dosage FormsShantaram Nangude*, Manisha ViteEvaluation of Antiulcer Activity of Moringa Oleifera Seed ExtractSwati S. Kansara*, Manmohan SinghalMarket Survey of Abortifacients to Explore Unethical Issues J. A. Patel, Dr. T. R. DesaiQuantitative Analysis of Berberine in an Ayurvedic Formulation-Rasayana Churna by UV SpectrophotometryH. Joshi, N. KanakiPulsatile Drug Delivery Systems: Current ScenarioDr.Upendra Kulkarni*, Sampada H.C, Hariprasanna R.C
ABSTRACT:Present Study was focused on Design and Development of in situ gel of Lomefloxacin HCL.Lomefloxacin HCL is an antibacterial agent which exhibits rapid precorneal elimination and poor ocular bioavailability, when given in the form of conventional ophthalmic solutions. To overcome this, an attempt has been made to formulate pH- triggered in situ gelling system of Lomefloxacin HCL to provide sustained release of drug based on polymeric carriers that undergo sol-to-gel transition upon change in pH. The Lomefloxacin HCL in situ gelling system formulated by using poly acrylic acid (Carbopol 940) and in combination with hydroxyl propyl methyl cellulose (HPMC) which acted as viscosity enhancing agent. The developed formulation was stable, non-irritant and provided sustained release over 8-hour period and it is a viable alternative to conventional eye drops.KEYWORDS:In situ gel, Cabopol 940, pH, Lomefloxacin HCL
ABSTRACT:An RP-HPLC method was developed and validated for the estimation of Lycopene in bulk drug and solid dosage forms. The chromatographic system was equipped with Inertsil ODS-3V, C-18, 150 X 4.6mm internal diameter with 5 micron particle size column and PDA detector set at 472 nm, in conjunction with a mobile phase of Methanol, Tetra Hydro Furan and Water in the ratio of 66:30:4 % v/v at a flow rate of 1.5 ml/min. The retention time of Lycopene was found to be 6.805 minute. The separation was performed at ambient temperature. Linearity was observed in the concentration range of 10-80µg/ml with correlation co-efficient 0.9997 and slope 78219.2.Percentage recovery obtained 99.92-100.14 %. The percentage Assay was found to be 100.51 to 102.64 %.The proposed method is precise, accurate, selective and rapid for the determination of lycopene in bulk drug and solid dosage forms. The proposed method is optimized and validated as per the International Conference on Harmonization (ICH) guidelines.KEYWORDS: RP-HPLC; Lycopene; Validation,; Solid Dosage Forms.
ABSTRACT:Antiulcer activity of seeds of Moringa Oleifera was studied in rats in which gastric ulcers were induced by oral administration of ethanol and pylorus ligation. Seeds extract of Moringa Oleifera was administered in the dose of 150 and 200 mg/kg orally. The antiulcer activity was assessed by determining and comparing the ulcer index in the test group with that of the vehicle control group. Gastric fluid total acidity and free acidity were estimated in pylorus ligated rats. Omeprazol was used as a reference drug. The results suggested that ethanolic extract of Moringa Oleifera possesses significant antiulcer activity.Keywords: Pylorus ligation, Moringa Oleifera, Omeprazol
ABSTRACT:The aim of the study was to explore unethical issues of abortifacients used in the market of Rajkot city in Gujarat. A prospective market survey study involving retailers, wholesalers and doctors (M.D.-Gynec) were selected in Rajkot city located in different areas. They were explained about the objective of the study and given a validated questionnaire. The questionnaire included the questions regarding most commonly used allopathic and ayurvedic abortifacients (abortion pills), % sale of allopathic verses ayurvedic drugs, % sale of drugs on prescription, degree of doctors prescribe the abortion medicines, age factor of patients, sale data in respect of month, most commonly side effects seen in patients due to usage of self medicated abortion pills, number of self medicated patients comes for treatment per month etc. This study highlights commonly used self medicated abortifacient drugs in the patient with marital status and age which gives many types of serious side effects. As per doctors opinion that ayurvedic abortion pills are not effective in the process of abortion. While in market survey ayurvedic abortion pills are more used than the allopathic abortion pills by patients. Hence detailed and scientifically designed research on ayurvedic abortifacients for its effectiveness in the abortion process and to discover the seriousness of side effects occurred on the usage of self medicated abortifacients by general public to save the public health is highly required.KEY WORDS : Abortifacients, self medication, Misoprost-200 tablet, Menstrojek Forte capsule, Rajkot.
ABSTRACT: Rasayana churna is a well known rejuvenating formulation of Ayurveda, consisting of guduchi (Tinospora cordifolia), gokhru (Tribulus terrestris) and amla (Embelica officinalis). A UV- spectrophotometric method for the quantitative determination of berberine in Rasayana churna was developed and validated. The method involved measurement of absorbance of sample solutions at the absorption maxima of berberine (348 nm). The interference from other compounds was eliminated by processing the crude drug and the formulations to isolate alkaloidal fraction from them. The method was validated by determining linearity, precision and accuracy as per the ICH guidelines. Berberine obeyed Beer's law in the concentration range of 2-20 µg/ml. The method proved to be quite accurate with a mean percentage recovery of 99.21%. Thus, the proposed method is simple, rapid, precise, accurate, and suitable for quantification of berberine content in samples of Rasayana churna. KEY WORDS: Berberine, Rasayana churna, UV-Spectrophotometry
ABSTRACT:Sustained release or controlled release dosage systems have large advantages over conventional drug delivery systems because of their lesser frequency of dose and controlled release of drug. Pulsatile drug delivery system is one such system which offers controlled release of drug at desired site and on required time. Its accuracy is attributed to circardian rhythm of the body and it releases drug in the form of pulse. The relation between physiology of disease and time along the day is discovered. Drug deliveries in the form of single-unit and multiple- unit systems are developed.KEYWORDS: Pulsatile Drug Delivery system, Controlled release dosage system, circardian rhythm