ABSTRACT:Liponiosomes represent a promising drug delivery module. They present a structure similar to liposome and noisome. Hence they can represent alternative vesicular systems with respect to liposomes, and niosomes due to the liponiosome ability to encapsulate different type of drugs within their multi environmental structure. Liponiosomes are thoughts to be better candidate’s drug delivery as compared to liposomes and niosomes due to various factors like cost, stability and wide range of drug delivery etc. Various types of drug deliveries can be possible using liponiosomes like targeting, ophthalmic, topical, parentral, etc. Keyword: Liponiosomes, Liposome, noisome, Targeting, Ophthalmic, Topical, Parentral.
ABSTRACT:Flame photometry (more accurately called flame atomic emission spectrometry) is a branch of atomic spectroscopy in which the species examined in the spectrometer are in the form of atoms. Flame photometry is suitable for qualitative and quantitative determination of several cations, especially for metals that are easily excited to higher energy levels at a relatively low flame temperature (mainly Na, K, Rb, Cs, Ca, Ba, Cu). The major cation of the extracellular fluid is sodium and intracellular cation found to be potassium. When the concentration level of the sodium cation in the human plasma decreases leads to cause Hyponatraemia and hypernatraemia when the level is raised. In case of potassium cation hypokalaemia (lowered plasma [K+]), hyperkalaemia (increased plasma [K+]) and hyperkaluria (increased urinary excretion of K+) The present article include the Comparative studies on Sodium and Potassium content Present in Water Sample Collected from Girna in Malegaon and Godavari ( Nasik) River.Key Words: Flame photometry, Sodium, Potassium.
ABSTRACT:Three simple, rapid, accurate, precise and cost-effective UV spectrophotometric methods and RP – HPLC have been developed and validated for simultaneous estimation of Levosulpiride and Rabeprazole Sodium in tablet dosage form. Method I is estimation using simultaneous equation method at 232 nm (λmax of Levosulpiride) and 284 nm (λmax of Rabeprazole Sodium). Method II is 1st order derivative method utilize absorbance measurement at 247 nm for Levosulpiride and 291.60 nm for Rabeprazole Sodium. Method III is RP-HPLC method for simultaneous estimation of Levosulpiride and Rabeprazole Sodium separation was achieved on a Phenomenexluna ODS C18 (250mm X 4.6 mm i.d., 5 μm particle size) with an mobile phase acetonitrile: 50 mM phosphate buffer pH 5 (adjusted with Sodium hydroxide) in the ratio of 55:45 v/v. The mobile phase at a flow rate of 1.0 ml/min, Injection volume 20μl and detection wavelength was kept at 288 nm. The retention time Levosulpiride and Rabeprazole Sodium was 2.31±0.1min and 3.85 ±0.1min, respectively. The linearity lies between 5-30 μg/ml for Levosulpiride and 2-12 μg/ml for Rabeprazole Sodium.The proposed conditions were successfully applied for the simultaneous estimation of both drugs in commercial tablet preparation and were validated according to ICH guidelines.KEYWORDS:Levosulpiride, Rabeprazole Sodium, UV spectrophotometry, Simultaneous equation method, Derivative method, RP-HPLC.
ABSTRACT:The on-line coupling of high-performance liquid chromatography (HPLC) principles to high-resolution NMR spectrometers offers a powerful tool for analyzing and characterizing complex chemical mixtures without the need of chemical separation. LC-NMR promises to be of great value in the analysis of complex mixtures of all types, particularly the analysis of natural products and drug-related metabolites in biofluids. However, the advantages of directly coupling NMR and HPLC instrumentation must be weighed against compromises in performance made to each technique to achieve a hyphenated system. While significant advances have been made in LC-NMR technology, a strong case can be made that HPLC purification of metabolites followed by conventional tube NMR is equally useful.KEYWORDS: LC-NMR, instrumentation, hyphenated system